Translational Regulation of caudal mRNA by Bicoid

The work of my PhD was on the evolution of translational regulation of caudal mRNA by Bicoid in Drosophila melanogaster and other insects. Quite a lot had been done already about this: Bicoid, a.k.a “the morphogen”, was found to be both a DNA-binding and RNA-binding protein. Besides its function as a transcription factor, it was also found to be the essential player in repressing the translation of the posterior patterning factor caudal. “Bicoid recognition elements (BRE)” to which Bicoid directly binds had been identified within the caudal 3’UTR.

My PhD work was done in the Averof lab, which has moved from Crete, Greece to Lyon, France.


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